| Phenate (Clomiphene Citrate) | ||||||||||||
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| PHENATE is a triarylethylene compound (related to chlorotrianisene and triparanol). It is a non-steroidal agent taken by mouth which stimulates ovulation in a high percentage of appropriately selected anovulatory women. The ovulatory response to cyclic PHENATE therapy appears to be mediated through increased output of pituitary gonadotrophins, which in turn stimulates the maturation and endocrine activity of the ovarian follicle and the subsequent development and function of the corpus luteum. The role of the pituitary is indicated by increased urinary excretion of gonadotrophins and the response of the ovary, as manifested by increased urinary oestrogen excretion. Unlabeled uses include stimulation of endogenous testosterone production in males. | ||||||||||||
| Indications | ||||||||||||
| The treatment of ovulatory failure in women wishing to become pregnant. PHENATE is indicated in patients with ovarian dysfunction. Commonly associated diagnoses include polycystic ovary syndrome, lactation amenorrhoea syndrome, psychogenic amenorrhoea, and certain cases of secondary amenorrhoea of undetermined aetiology. An additional indication is post-oral contraceptive amenorrhoea. | ||||||||||||
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